United States President Donald Trump reaffirmed on Friday his administration’s determination to prevent Iran from acquiring nuclear weapons, stressing that the threat could endanger lives globally. “They can’t have a nuclear weapon,” Trump said. “I want Iran to be great, prosperous, and terrific. I stopped them once, they were broke and didn’t have money for Hamas, for Hezbollah.” He warned that if Iran succeeds, “your life will be in great danger.”

Trump’s remarks came a day before the second round of nuclear talks between the United States and Iran commenced in Rome. The US delegation, led by Special Envoy for the Middle East Steve Witkoff, arrived late to the meeting, held at the residence of the Omani ambassador. The discussions follow last week’s initial round and center on Iran’s proposed three-stage plan, which includes a gradual reduction of uranium enrichment in exchange for the easing of US sanctions.

On Iran’s side, Foreign Minister Abbas Araghchi has been active in diplomatic circles, recently visiting Moscow and planning to travel to Beijing next week. Araghchi emphasized the importance of Russia and China’s roles in the evolving negotiations, describing their contributions as “very important and constructive.”

Despite Iran’s expressed readiness for diplomacy, Araghchi cast doubt on the sincerity of the United States. “Unrealistic” American demands, he warned, would decrease the chances of reaching an agreement. He also reiterated Iran’s resistance to external pressure. “We have proven in the past that we do not respond to force, pressure, and threats,” Araghchi said in an interview with RT. “We resist threats and pressure.”

As talks proceed, both sides appear cautious. Araghchi confirmed Iran’s preference for the diplomatic path but did not rule out other responses if negotiations break down. “If these negotiations lead to difficult conditions, we know how to defend ourselves very well,” he said, adding that Tehran is prepared for all outcomes.

The outcome of the Rome talks may shape the future of US-Iran relations and efforts to curb nuclear proliferation in the Middle East. With the stakes high and trust fragile, the next phase of dialogue will likely determine whether diplomacy or confrontation prevails.